Acute effects of cadmium on the spot Leiostomus xanthurus (teleostei): tissue distribution and renal ultrastructure

Journal Article · Sat Mar 01 00:00:00 EST 1980 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398009529852· OSTI ID:5366044

Hawkins, W E; Tate, L G; Sarphie, T G

Spot (Leiostomus xanthurus) was exposed to 1, 5, 10, 15, and 25 ppM cadmium chloride for 48 h. Analysis by atomic absorption spectrophotometry showed that cadmium accumulated mainly in the liver, followed by heart, gut, kidney, and gill. Brain and body muscle did not concentrate the metal. Electron microscopy showed that the proximal tubule cells were severely affected by cadmium levels of 10, 15, and 25 ppM. The proximal tubule cells exhibited responses that ranged from an increase in heterogeneous bodies to epithelial desquamation. Mitochondria of degenerating proximal tubule cells showed changes similar to metal-poisoned mammalian kidney cells. Some mitochondria were contracted and dense while others were swollen with granular matrices and focal electron densities. In exposures of 25 ppM, Bowman's space of the renal corpuscle was swollen and often contained cellular debris. This study showed that after acute exposure to cadmium the metal accumulated mainly in visceral organs of the spot and at levels of 10 ppM and greater resulted in severe damage to proximal tubule cells of the kidney.

• Research Organization: Univ. of South Alabama, Mobile
• OSTI ID: 5366044
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 6:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM
BIOLOGICAL EFFECTS
TISSUE DISTRIBUTION
KIDNEYS
INJURIES
TUBULES
ULTRASTRUCTURAL CHANGES
ACUTE EXPOSURE
ANIMAL CELLS
DOSE-RESPONSE RELATIONSHIPS
FISHES
GASTROINTESTINAL TRACT
GILLS
HEART
LIVER
MITOCHONDRIA
TOXICITY
ANIMALS
AQUATIC ORGANISMS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
GLANDS
METALS
MORPHOLOGICAL CHANGES
ORGANOIDS
ORGANS
RESPIRATORY SYSTEM
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551000 - Physiological Systems
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)