X-ray-induced chromosome aberrations in Down lymphocytes: an explanation of their increased sensitivity

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860030109· OSTI ID:5363793

Preston, R J

Unstimulated lymphocytes from individuals with Down Syndrome (trisomy 21) are more sensitive to the induction of dicentric and ring aberrations by X rays than normal lymphocytes. Several explanations involving the more rapid rejoining of X-ray--induced lesions in Down cells have been offered. It is shown here that the repair of the DNA damage converted into chromosome aberrations is more rapid in Down cells than normal cells. This more rapid repair results in a higher probability of producing chromosomes aberrations, and hence higher aberration frequencies in Down than normal cells.

• OSTI ID: 5363793
• Journal Information: Environ. Mutagen.; (United States), Vol. 3:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
BIOLOGICAL RADIATION EFFECTS
DOWNS SYNDROME
PATHOLOGY
LYMPHOCYTES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BIOLOGICAL REPAIR
CHROMOSOMAL ABERRATIONS
DNA
RADIOINDUCTION
X RADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HEREDITARY DISEASES
IONIZING RADIATIONS
KINETICS
LEUKOCYTES
MALFORMATIONS
MATERIALS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
REACTION KINETICS
RECOVERY
REPAIR
SOMATIC CELLS
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