Metabolism of D, L-/sup 3/H-norepinephrine in essential hypertension

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Clin. Exp. Hypertens.; (United States)

DOI:https://doi.org/10.3109/10641968109033711· OSTI ID:5362312

Gitlow, S; Dziedzic, S; Dziedzic, L; Roubein, I

Defective control of the cardiovascular system by the sympathetic nerves continues to be incriminated as the potential primary physiologic defect in essential hypertension (EH). The need to measure sympathetic tone has progressed from physiologic mensuration by assessment of reflex and pharmacological responses to the recent assay of norepinephrine (NE) and its congeners in both urine and plasma. The way in which the body handles D,L-B-/sup 3/H-NE represents yet another technique by which to evaluate sympathetic function. Previous studies of EH by this method demonstrated more rapid plasma disappearance of /sup 3/H-NE as well as elevated 24 hour tritium accumulation in the urine following D,L-B-/sup 3/H-NE injection. The present study of 7 normotensive subjects and 7 patients with EH was designed to depict more precisely these abnormalities in /sup 3/H-NE-metabolism. Following a one minute injection of 8 micrograms D,L-B-/sup 3/H-NE, (200 microCi) intravenously, the excretion of unlabeled endogenous metabolites and their labeled congeners was assayed. By these means one could estimate catecholamine synthesis, turnover of the labeled pools, and by comparison of relative specific activities of the metabolites, gain some insight into the distribution of the injected material. Alternative catabolic pathways were evaluated by measurement of the excretion of /sup 3/H/sub 2/O. Patients with EH excreted more label per 24 hours, revealed a more rapid decline of /sup 3/H2O excretion and lower specific activity of normetanephrine (NM). These findings are compatible with changes in pool dynamics and distribution of administered label which gave additional support to the concept of adrenergic dysfunction in association with essential hypertension.

• Research Organization: Department of Medicine, Mount Sinai School of Medicine, New York
• OSTI ID: 5362312
• Journal Information: Clin. Exp. Hypertens.; (United States), Vol. 3:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HYPERTENSION
PHYSIOLOGY
NORADRENALINE
BIOLOGICAL ACCUMULATION
METABOLISM
TRITIUM COMPOUNDS
BLOOD PLASMA
MICE
NERVES
PATIENTS
URINE
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
HORMONES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NERVOUS SYSTEM
NEUROREGULATORS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
WASTES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
551000 - Physiological Systems
550900 - Pathology