Functional consequences of prenatal methylmercury exposure: effects on renal and hepatic responses to trophic stimuli and on renal excretory mechanisms
The effects of prenatal exposure to methylmercury on the functional development of renal and hepatic response systems was examined in the developing rat. Methylmercury produced an elevation of basal activity of renal ornithine decarboxylase (ODC, an enzyme involved in regulation of cellular maturation) and an eventual relative hypertrophy; liver ODC was reduced and hypertrophy was not evident. In contrast, the reactivity of liver ODC to trophic stimulants (vasopressin, isoproterenol) was markedly enhanced by prenatal methylmercury exposure, whereas renal ODC responses were much less affected (vasopressin) or actually reduced (isoproterenol). Targeted actions of methylmercury on renal excretory function were also prominent, with increased fractional excretions urea and electrolytes and an eventual reduction in glomerular filtration as assessed by creatinine clearance. These studies show that doses of methylmercury ordinarily associated with selective actions on development of neurobehavioral patterns also influence the functional ontogeny of other organ systems; furthermore, the fact that the target tissues are different for prenatal vs postnatal methylmercury exposure, indicates that the functional teratology of methylmercury exhibits critical periods of sensitivity.
- Research Organization:
- Duke Univ., Durham, NC (USA). Dept. of Pharmacology
- OSTI ID:
- 5359646
- Report Number(s):
- PB-88-144324/XAB
- Resource Relation:
- Other Information: Pub. in Toxicology Letters, Vol. 34, 231-245(1986)
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
METHYLMERCURY
BIOLOGICAL EFFECTS
BIOCHEMISTRY
HEART
KIDNEYS
LIVER
PRENATAL EXPOSURE
RATS
RENAL CLEARANCE
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
CHEMISTRY
CLEARANCE
DIGESTIVE SYSTEM
EXCRETION
GLANDS
MAMMALS
MERCURY COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
550900* - Pathology
560300 - Chemicals Metabolism & Toxicology