Deleterious background selection with recombination

Journal Article · Fri Dec 01 00:00:00 EST 1995 · Genetics

OSTI ID:535353

Hudson, R R ^[1]; Kaplan, N L ^[2]

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1. Univ. of California, Irvine, CA (United States)
2. National Institute of Environmental Health Sciences, Research Triangle Park, NC (United States)

An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have been observed at loci near the centromeres of the third chromosome of D. melanogaster. However, the low levels of variation observed near the tips of this chromosome are not predicted using currently available estimates of the deleterious mutation rate and of selection coefficients. If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model. 33 refs., 4 figs., 1 tab.

• OSTI ID: 535353
• Journal Information: Genetics, Vol. 141, Issue 4; Other Information: PBD: Dec 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
DROSOPHILA
GENETICS
GENES
GENE RECOMBINATION
GENETIC VARIABILITY
GENE MUTATIONS
GENETIC MAPPING
MUTATION FREQUENCY
NUCLEOTIDES
ANALYTIC FUNCTIONS
CHROMOSOMES
CHROMOSOMAL ABERRATIONS
CENTROMERES