Studies on the tumor initiating, tumor promoting, and tumor co-initiating properties of respiratory carcinogens
With mouse skin as the bioassay model, the multifaceted behavior of chemicals and mixtures can be elucidated using the protocols of tumor initiation, tumor promotion, tumor co-initiation, and complete carcinogenesis. In addition to studies with individual respiratory carcinogens, we report the tumorigenic and carcinogenic effects of complex environmental mixtures. We sought to compare the potency of human respiratory carcinogens, based on epidemiological data, with the bioassay potency data obtained from mouse skin tumor initiation and mouse skin complete carcinogenesis experiments as well as the bioassay potency data obtained from short-term genetic toxicology bioassays. Three human respiratory carcinogens were used: emissions from coke ovens, emissions from roofing tar pots, and cigarette smoke. When the potency obtained from mouse skin tumor initiation experiments of these materials was compared with the potency based on human respiratory cancer, a surprisingly close correlation was observed. 10 refs., 18 figs., 5 tabs. (DT)
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.; Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5353326
- Report Number(s):
- CONF-8406210-2; ON: DE85016387
- Resource Relation:
- Conference: Symposium on tumor promotion and enhancement in the etiology of human and experimental respiratory tract carcinogenesis, Williamsburg, VA, USA, 17 Jun 1984; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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ASPHALTS
CARCINOGEN SCREENING
BENZOPYRENE
BERYLLIUM SULFATES
COAL TAR
EXHAUST GASES
NICKEL SULFATES
PYRENE
TOBACCO SMOKES
EXPERIMENTAL DATA
MICE
NEOPLASMS
PHORBOL ESTERS
SKIN
AEROSOLS
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
AROMATICS
BERYLLIUM COMPOUNDS
BITUMENS
BODY
CARCINOGENS
COLLOIDS
CONDENSED AROMATICS
DATA
DISEASES
DISPERSIONS
ESTERS
FLUIDS
GASEOUS WASTES
GASES
HYDROCARBONS
INFORMATION
MAMMALS
NICKEL COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
RESIDUES
RODENTS
SCREENING
SMOKES
SOLS
SULFATES
SULFUR COMPOUNDS
TAR
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
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560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)