Increased release of norepinephrine and dopamine from canine kidney during bilateral carotid occlusion

Journal Article · Sun Feb 01 00:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5351775

Bradley, T; Hjemdahl, P; DiBona, G F

The renal overflow of norepinephrine (NE) and dopamine (DA) to plasma from the innervated kidney was studied at rest and during sympathetic nervous system activation by bilateral carotid artery occlusion (BCO) in vagotomized dogs under barbiturate or barbiturate/nitrous oxide anesthesia. BCO elevated arterial pressure and the arterial plasma concentration of NE, DA, and epinephrine (Epi). Renal vascular resistance (renal arterial pressure kept constant) increased by 15 +/- 7% and the net renal venous outflows (renal veno-arterial concentration difference x renal plasma flow) of NE and DA were enhanced. To obtain more correct estimates of the renal contribution to the renal venous catecholamine outflow, they corrected for the renal extraction of arterial catecholamines, assessed as the extractions of (/sup 3/H)NE, (/sup 3/H)DA, or endogenous Epi. The (/sup 3/H)NE corrected renal NE overflow to plasma increased from 144 +/- 40 to 243 +/- 64 pmol-min/sup -1/ during BCO, which, when compared with a previous study of the (/sup 3/H)NE corrected renal NE overflow to plasma evoked by electrical renal nerve stimulation, corresponds to a 40% increase in nerve impulse frequency from approx. 0.6 Hz. If the renal catecholamine extraction was not taken into account the effect of BCO was underestimated. The renal DA overflow to plasma was about one-fifth of the NE overflow both at rest and during BCO, indicating that there was no preferential activation of noradrenergic or putative dopaminergic nerves by BCO.

• Research Organization: Karolinska Institutet, Stockholm, Sweden
• OSTI ID: 5351775
• Journal Information: Am. J. Physiol.; (United States), Vol. 252:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
MEMBRANE TRANSPORT
KIDNEYS
PHYSIOLOGY
NORADRENALINE
TRITIUM COMPOUNDS
BLOOD FLOW
BLOOD PRESSURE
CAROTID ARTERIES
CATECHOLAMINES
DOGS
NERVES
STIMULATION
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DRUGS
HORMONES
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques