Effect of naphthalene on cytochrome oxidase activity
Previous reports have demonstrated that naphthalene inhibits oxygen consumption in Daphnia magna tissue culture cells, and intact mitochondria and submitochondrial particles. These studies were extended to algal mitochondrial respiration as well as photosynthetic activity. The authors were able to demonstrate the specific site of apparent respiratory inhibition to be coenzyme Q (ubiquinone, UQ) and later to demonstrate the molecular basis of this inhibition at ubiquinone. The authors previously could not demonstrate an effect of naphthalene on cytochrome oxidase activity. However, the observation that naphthalene can stimulate respiration in algae prompted the reinvestigation of the effect of naphthalene on the kinetics of cytochrome oxidase. Cytochrome oxidase is a multi-subunit membranous protein responsible for the oxidation of cytochrome c and the reduction of molecular oxygen to water. Because of the complicated nature and mechanism of this enzyme, the potential exists for multiple and possibly opposite effects of naphthalene on its function.
- Research Organization:
- Oklahoma State Univ., Stillwater
- OSTI ID:
- 5348218
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 40:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CYTOCHROME OXIDASE
BIOCHEMISTRY
NAPHTHALENE
BIOLOGICAL EFFECTS
CATTLE
ENZYME ACTIVITY
HEART
MITOCHONDRIA
ANIMALS
AROMATICS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CHEMISTRY
CONDENSED AROMATICS
DOMESTIC ANIMALS
ENZYMES
HAEM DEHYDROGENASES
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
RUMINANTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology