Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.11.3822· OSTI ID:5347710

Muellbacher, A; Hume, D; Braithwaite, A W; Waring, P; Eichner, R D

The fungal metabolite gliotoxin at low concentrations prevents mitogen stimulation of mature lymphocytes as a result of gliotoxin-induced genomic DNA degradation. Bone marrow, on the other hand, contains a subpopulation of cells resistant to gliotoxin at similar concentrations. This population includes the hemopoietic progenitor cells that grow in vitro in response to appropriate colony-stimulating factors and cells that form colonies in the spleens of lethally irradiated recipients. Gliotoxin treatment of lymph node cell-enriched bone marrow significantly delayed the onset of graft-versus-host disease in fully allogeneic bone marrow chimeras.

• Research Organization: Australian National Univ., Canberra, ACT (Australia)
• OSTI ID: 5347710
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:12
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
LETHAL IRRADIATION
DNA
BIODEGRADATION
TOXINS
BIOLOGICAL EFFECTS
CELL PROLIFERATION
COBALT 60
DNA REPLICATION
FUNGI
GAMMA RADIATION
GRAFT-HOST REACTION
INHIBITION
LYMPHOCYTES
MICE
SPLEEN CELLS
THYMIDINE
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTIGENS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL REACTIONS
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DECOMPOSITION
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLANTS
PYRIMIDINES
RADIATIONS
RADIOISOTOPES
RIBOSIDES
RODENTS
SOMATIC CELLS
TOXIC MATERIALS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology
560152 - Radiation Effects on Animals- Animals