Antidotal effectiveness of activated charcoal in rats

Thesis/Dissertation · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5347325

Curd-Sneed, C D

This study was designed to investigate the relative adsorption of radiolabeled /sup 14/C-sodium pentobarbital by three types of activated charcoal. Factors affection adsorption of the drug by SuperChar, United States Pharmacopeia (USP), and Darco G-60 activated charcoals with surface areas of 2800-3500 m2/g, 1000 m/sup 2//g, and 650 m/sup 2//g, respectively, were studied both in vitro and in vivo. For in vitro experiments, the drug was dissolved in water of 70% sorbitol (w/v), and the maximum binding capacity and dissociation constants for each of the charcoals were calculated. Rank order of maximum binding capacity was directly proportional to charcoal surface area in both water and sorbitol, while the dissociation constants for the charcoals in water were not different. For in vivo experiments, absorption of orally administered sodium pentobarbital (40 mg/kg) was studied in rats with and without activated charcoal administration. The results of this research suggest that: (1) SuperChar given in water possesses the greatest antidotal efficacy, (2) sorbitol induced catharsis does not reduce oral absorption of sodium pentobarbital, and (3) sorbitol enhances the antidotal efficacy of USP charcoal.

• Research Organization: Louisiana State Univ., Shreveport (USA)
• OSTI ID: 5347325
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHARCOAL
CHEMICAL BONDS
COMPARATIVE EVALUATIONS
NEMBUTAL
ADSORPTION
CARBON 14 COMPOUNDS
ORAL ADMINISTRATION
RATS
RESPONSE MODIFYING FACTORS
SORBITOL
TRACER TECHNIQUES
ADSORBENTS
ANESTHETICS
ANIMALS
AZINES
BARBITURATES
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIURETICS
DRUGS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PYRIMIDINES
RODENTS
SACCHARIDES
SORPTION
VERTEBRATES
550201* - Biochemistry- Tracer Techniques