Specific binding of a ligand of sigma-opioid receptors - N-allylnormetazocine (SKF 10047) - with liver membranes

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Sov. J. Bioorg. Chem. (Engl. Transl.); (United States)

OSTI ID:5346917

Samovilova, N N; Yarygin, K N; Vinogradov, V A

A ligand of the sigma-opioid receptors - N-allylnormetazocine (SKF 10047) -binds specifically and reversible with rat liver membranes. In relation to a number of properties, the sites binding SKF 10047 in the liver are similar to the sigma-opioid receptors of the central nervous system. They do not interact with classical opiates (morphine, naloxone) and with opioid peptides, but bind well benzomorphans (bremazocine, SKF 10047) and a number of compounds of different chemical structures with a pronounced psychtropic action (haloperidol, imipramine, phencyclidine, etc.).

• Research Organization: All-Union Cardiologic Research Center, Moscow (USSR)
• OSTI ID: 5346917
• Journal Information: Sov. J. Bioorg. Chem. (Engl. Transl.); (United States), Vol. 11:10; Other Information: Translated from Bioorganicheskaya Khim.; 11: No. 10, 1380-1384(Oct 1985)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CELL MEMBRANES
BINDING ENERGY
RADIORECEPTOR ASSAY
NARCOTICS
RECEPTORS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
DISSOCIATION
GUINEA PIGS
INHIBITION
LABELLING
LIGANDS
LIVER CELLS
MAN
MICE
NERVE CELLS
RATS
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ENERGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
REACTION KINETICS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES
550301* - Cytology- Tracer Techniques