Capsaicin pretreatment prevents disruption of the blood-aqueous barrier in the rabbit eye
Capsaicin, the irritating agent of red pepper, produces ocular inflammation through a neurogenic mechanism. The present study is concerned with the long-term effects of capsaicin pretreatment on the capacity of the eye to respond to different inflammatory stimuli. Following retrobulbar injection of capsaicin to rabbits the aqueous flare response induced by subsequent infrared irradiation (IR) of the iris, subcutaneously administered alpha-melanocyte-stimulating hormone (alpha-MSH) and exogenously administered prostaglandin E2 (PGE2) was reduced greatly. In the case of IR and alpha-MSH the reduced responsiveness was manifest for several weeks after capsaicin pretreatment, involving first the capsaicin-treated eye, but later also the contralateral control eye. After 2-3 months the aqueous flare response was normal in both eyes. In the case of PGE2 the responsiveness was reduced for a shorter time; after 3 weeks the response was normal in both eyes. The results indicate that all three stimuli tested are at least partly dependent upon an intact sensory innervation to disrupt the blood-aqueous barrier, but that the mechanism of action of PGE2 is different from that of IR and alpha-MSH.
- Research Organization:
- Department of Experimental Ophthalmology, University Eye Clinic, Lund, Sweden
- OSTI ID:
- 5345978
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Vol. 24:6
- Country of Publication:
- United States
- Language:
- English
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CAPSICUM
TOXICITY
EYES
INFLAMMATION
BLOOD
HORMONES
PROSTAGLANDINS
RABBITS
ANIMALS
BIOLOGICAL MATERIALS
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BODY AREAS
BODY FLUIDS
FACE
HEAD
MAMMALS
MATERIALS
ORGANS
PATHOLOGICAL CHANGES
PLANTS
SENSE ORGANS
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VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)