The diagnostic value of the fibrinogen/fibrin fragment E antigen assay in clinically suspected deep vein thrombosis
We have evaluated the fibrinogen/fibrin fragment E antigen assay as a diagnostic test in patients with clinically suspected venous thrombosis by comparing the results of this assay with venography in 272 patients. The result of the fragment E antigen assay was elevated in 79 of 80 patients with positive venograms for recent venous thrombosis (sensitivity 99%) and within the normal range in 161 of 192 patients with normal venograms (specificity 84%). The fragment E assay was also evaluated in 130 medical and surgical controls without evidence of venous thrombosis by leg scanning and the test was found to be relatively nonspecific. However, in the patient group under study, a correct clinical diagnosis of no thrombosis, based on a normal fragment E result, was made in 161 of 162 cases (negative predictive value of 99%). Therefore, a normal test result effectively excludes a diagnosis of venous thrombosis in clinically symptomatic patients. The assay, as currently performed, is technically demanding and takes 24 hr to complete. Therefore, it will have to be simplified before it can be applied to clinical practice.
- Research Organization:
- Department of Medicine, Chedoke-McMaster Hospital, Hamilton, Ontario, Canada
- OSTI ID:
- 5345842
- Journal Information:
- Blood; (United States), Vol. 59:2
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANTIGENS
BIOASSAY
THROMBOSIS
DIAGNOSIS
VEINS
BIOMEDICAL RADIOGRAPHY
FIBRIN
FIBRINOGEN
PATIENTS
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COAGULANTS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOLOGY
SCLEROPROTEINS
VASCULAR DISEASES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
551000 - Physiological Systems