The thermal sensitivity of normal and ataxia telangiectasia human fibroblasts

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90454-0· OSTI ID:5344564

Raaphorst, G P; Azzam, E I

Human normal and ataxia telangiectasia (AT) heterozygote and homozygote cell strains were heated at 42.0 and 45.0/sup 0/C to determine their thermal responses. All cell strains had approximately the same thermal sensitivity and were less thermally sensitive than Chinese hamster cells or many other rodent cell lines reported in the literature. No shoulders were observed on the survival curves for heating at 42.0 or 45.0/sup 0/C. Thermal tolerance developed in both the normal and AT cell strains with heating for prolonged intervals at 42.0/sup 0/C.

• Research Organization: Atomic Energy of Canada, Ltd., Pinawa, Manitoba
• OSTI ID: 5344564
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FIBROBLASTS
TEMPERATURE EFFECTS
ANIMAL CELLS
HAMSTERS
HUMAN POPULATIONS
HYPERTHERMIA
SENSITIVITY
THERMAL STRESSES
ANIMALS
BODY TEMPERATURE
CONNECTIVE TISSUE CELLS
MAMMALS
POPULATIONS
RODENTS
SOMATIC CELLS
STRESSES
VERTEBRATES
560201* - Thermal Effects- Cells- (-1987)