Role of toxicological interactions in chemical carcinogenesis
Toxicological interactions may occur not only when exposure to two or more chemicals is simultaneous, but also when exposures are separated in time. Often the sequence of exposure determines the nature of the toxicological response. This is illustrated with the two hindered phenolic antioxidants, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA). Evidence available suggests that in certain tissues exposure to BHT first and then to a carcinogen is without significant consequences, whereas exposure to BHT after a carcinogen may enhance tumor formation. On the other hand, exposure to BHA before carcinogen administration often has a protective effect, whereas exposure to BHA after a carcinogen sometimes protects and sometimes is without any influence. Mechanisms underlying these interactions may be induction of mixed function oxidases, production of cell hyperplasia or other, as yet ill-defined, events such as modification of biological reactivity.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5343722
- Report Number(s):
- CONF-8310242-1; ON: DE84003322
- Resource Relation:
- Conference: 2. international meeting of chemical carcinogenesis: xenobiotics and biotransformation, Alghero, Italy, 11 Oct 1983
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
3-METHYLCHOLANTHRENE
BIOLOGICAL EFFECTS
ANISOLE
BENZOPYRENE
LIVER
NEOPLASMS
LUNGS
MIXED-FUNCTION OXIDASES
BIOSYNTHESIS
NITROSAMINES
PHENOLS
URETHANE
MICE
RESPONSE MODIFYING FACTORS
TIME DEPENDENCE
AMINES
ANIMALS
AROMATICS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISEASES
ENZYMES
ETHERS
GLANDS
HYDROCARBONS
HYDROXY COMPOUNDS
MAMMALS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
POLYCYCLIC AROMATIC HYDROCARBONS
RESPIRATORY SYSTEM
RODENTS
SYNTHESIS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)