Effects of dextran 70 versus crystalloids in the microcirculation of porcine hemorrhagic pancreatitis

Journal Article · Sun Jun 01 00:00:00 EDT 1986 · Surg. Gynecol. Obstet.; (United States)

OSTI ID:5327803

Lehtola, A; Kivilaakso, E; Puolakkainen, P; Karonen, S L; Lempinen, M; Schroeder, T

The cause of hemodynamic changes occurring during acute pancreatitis remains obscure. Using a pig model of acute hemorrhagic pancreatitis and the reference sample method with 113Tin and 46 Scandium labelled microspheres, blood flow to organs was determined before and five hours after the induction of pancreatitis. Blood pressure, pulse rate and cardiac output were measured hourly. There were two treatment groups. The first group received dextran 70 (5.7 milliliters per kilogram per hour) and saline solution (7.5 milliliters per kilogram per hour) in sufficient amounts to maintain cardiac output at the initial (prepancreatic) level. The second group received saline solution (26 milliliters per kilogram per hour) only and during the experiment the cardiac output was allowed to decrease to approximately one-half of the initial level. In the dextran 70 group, blood flow in various organs stayed at the initial level or was slightly increased. However, in the saline solution group there was a marked and significant decrease in the blood flow in all organs except the antral mucosa, gallbladder and adrenal glands. The changes in the pancreatic fraction of the cardiac output during the experiment were similar to those of other organs in respective treatment groups. In conclusion, adequate infusion of dextran maintains cardiac output and organ microcirculation at the initial level during the early phase of acute hemorrhagic pancreatitis. It is suggested that the hemodynamic changes which develop during acute pancreatitis are mainly secondary to the ensuing hypovolemia and not direct consequences of the pancreatic inflammatory process.

• Research Organization: Helsinki Univ. Central Hospital, Finland
• OSTI ID: 5327803
• Journal Information: Surg. Gynecol. Obstet.; (United States), Vol. 6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DEXTRAN
BIOLOGICAL EFFECTS
PANCREAS
HEMORRHAGE
INFLAMMATION
BIOLOGICAL MODELS
BLOOD CIRCULATION
BLOOD FLOW
BLOOD PRESSURE
MICROSPHERES
SCANDIUM 46
SWINE
TIN 113
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD SUBSTITUTES
BODY
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
RADIOISOTOPES
SACCHARIDES
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
TIN ISOTOPES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques