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Title: Effects of dimethylformamide (DMF) on coagulation and platelet activity

Abstract

The effects of dimethylformamide (DMF) on hemostatic functions, especially on platelet activity, were examined both in vitro and in vivo in 15 workers exposed to DMF (27 mg/m3, median value). Twenty-eight control subjects who were not exposed to DMF, but comparable for age, anthropometric data, and smoking habits, were also studied. Workers exposed to DMF showed a decrease in the number of platelets and had longer coagulation times, probably due to a change caused by DMF on the membrane receptor of platelets and on the phospholipid components of the clotting system.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Pavia, Italy
OSTI Identifier:
5324131
Resource Type:
Journal Article
Journal Name:
Arch. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FORMAMIDE; TOXICITY; BLOOD COAGULATION; BLOOD PLATELETS; COLLAGEN; INHIBITION; LIVER; OCCUPATIONAL EXPOSURE; PERSONNEL; AMIDES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DIGESTIVE SYSTEM; GLANDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PROTEINS; SCLEROPROTEINS; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)

Citation Formats

Imbriani, M, Ghittori, S, Prestinoni, A, Longoni, P, Cascone, G, and Gamba, G. Effects of dimethylformamide (DMF) on coagulation and platelet activity. United States: N. p., 1986. Web. doi:10.1080/00039896.1986.9937415.
Imbriani, M, Ghittori, S, Prestinoni, A, Longoni, P, Cascone, G, & Gamba, G. Effects of dimethylformamide (DMF) on coagulation and platelet activity. United States. https://doi.org/10.1080/00039896.1986.9937415
Imbriani, M, Ghittori, S, Prestinoni, A, Longoni, P, Cascone, G, and Gamba, G. 1986. "Effects of dimethylformamide (DMF) on coagulation and platelet activity". United States. https://doi.org/10.1080/00039896.1986.9937415.
@article{osti_5324131,
title = {Effects of dimethylformamide (DMF) on coagulation and platelet activity},
author = {Imbriani, M and Ghittori, S and Prestinoni, A and Longoni, P and Cascone, G and Gamba, G},
abstractNote = {The effects of dimethylformamide (DMF) on hemostatic functions, especially on platelet activity, were examined both in vitro and in vivo in 15 workers exposed to DMF (27 mg/m3, median value). Twenty-eight control subjects who were not exposed to DMF, but comparable for age, anthropometric data, and smoking habits, were also studied. Workers exposed to DMF showed a decrease in the number of platelets and had longer coagulation times, probably due to a change caused by DMF on the membrane receptor of platelets and on the phospholipid components of the clotting system.},
doi = {10.1080/00039896.1986.9937415},
url = {https://www.osti.gov/biblio/5324131}, journal = {Arch. Environ. Health; (United States)},
number = ,
volume = 2,
place = {United States},
year = {Sat Mar 01 00:00:00 EST 1986},
month = {Sat Mar 01 00:00:00 EST 1986}
}