Role of Ah-receptor in suppression of in vivo antibody response by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on exposure conditions

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5320804

Holsapple, M P; Snyder, N K; Blair, R E; Morris, D L ^[1]; Gokani, V ^[2]

---

1. MCV/VCU, Richmond, VA (United States)
2. National Inst. of Occupational Health, Gjarat (India)

The authors have previously reported that subchronic exposure to 2,7,-DCDD, a dioxin congener with very weak affinity for the Ah-receptor, produces a dose-related suppression of the in vivo Ab response, but has no effect on liver induction. In the present study the authors have compared the effect of acute or subchronic exposure to TCDD in B6C3F1 and DBA/2 mice. Acute exposure to TCDD produced a marked suppression in B6C3F1 mice but had much less effect in the DBA/2 mice. Subchronic exposure produced comparable suppression in both strains - exposure to 1.4 ug/kg TCDD suppressed the Ab response by 52% in B6C3F1 mice and by 74% in DBA/2 mice, respectively. Both acute and subchronic exposure produced a dose-related increase in liver weight in B6C3F1 mice; but neither type of exposure produced any changes in the liver weights of DBA/2 mice. The authors have confirmed that the Ah-receptor appears to play a role in the immunosuppression by a single exposure to relatively high doses, and have suggested that it plays a minimal role in the immunosuppression by daily exposure to much lower doses.

• OSTI ID: 5320804
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIOXIN
BIOLOGICAL EFFECTS
LYMPHOKINES
RECEPTORS
ANTIBODIES
IMMUNOSUPPRESSION
IN VIVO
LIVER
METABOLISM
BODY
DIGESTIVE SYSTEM
GLANDS
GROWTH FACTORS
HETEROCYCLIC COMPOUNDS
MEMBRANE PROTEINS
MITOGENS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PROTEINS
560300* - Chemicals Metabolism & Toxicology