An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation
- Institute of Medicobiological Problems of USSR, Ministry of Health, Moscow (USSR)
A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experimental data for bone marrow and blood lymphocytes of rats continuously exposed to gamma radiation in a wide range of dose rates. The model reproduces the lymphopoiesis dynamics that we observed in our experiment, in particular, the radiation hormesis at low dose rates, the reduction of lymphopoiesis at intermediate dose rates, and extinction of lymphopoiesis at high dose rates of continuous radiation. The possible explanation of the hormesis is suggested by the framework of the model. The model can be used for predicting the lymphopoiesis dynamics in mammals under continuous irradiation.
- OSTI ID:
- 5318537
- Journal Information:
- Health Physics; (United States), Vol. 61:1; ISSN 0017-9078
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
RADIATION INJURIES
MATHEMATICAL MODELS
CHRONIC IRRADIATION
DIFFERENTIAL EQUATIONS
GAMMA RADIATION
RATS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EQUATIONS
INJURIES
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals