Role of zinc in maintenance of metabolic control in juvenile diabetes

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5315990

Molnar, I G; Jackson, R L; Logan, J; Bleich, D

Skin and its outgrowth are sensitive to differences in trace element nutrition. However, an inert metabolic substance appears to have an ideal structure in determining trace element nutritional status as a reflection of dietary intake over a period of time. A previous study had indicated normal hair zinc levels were associated with fair to good metabolic control in diabetic children. The present study aimed to determine if a relationship exists between hair zinc concentration and degree of metabolic control. Subjects ranged in age from 3.5 to 13.5 years and had been diabetic from 0.25 to 5.5 years. Biochemical variables considered as indices of control were: insulin required (U/kg) and blood glucose, HbA/sub 1/C and glucagon levels. Growth ratings and caloric intake wee also considered. Hair samples from 25 diabetic children showed that lower levels of zinc (< 100 ..mu..g/ml) were associated with elevated HbA/sub 1/C (> 7.5%) and fair to poor overall control rating. Data support a possible role for zinc in maintenance of metabolic control in diabetic children and indicate the need for further experimental studies of the beneficial effect of dietary zinc supplementation.

• Research Organization: Lincoln Univ., Jefferson City, MO
• OSTI ID: 5315990
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CHILDREN
DIABETES MELLITUS
ZINC
BIOLOGICAL EFFECTS
INTAKE
CHEMICAL COMPOSITION
HAIR
METABOLISM
NUTRITION
TISSUE DISTRIBUTION
AGE GROUPS
BODY
DISEASES
DISTRIBUTION
ELEMENTS
ENDOCRINE DISEASES
METABOLIC DISEASES
METALS
ORGANS
SKIN
560306* - Chemicals Metabolism &amp; Toxicology- Man- (-1987)
550900 - Pathology