Toxicology and carcinogenesis studies of ethylene oxide (CAS No. 75-21-8) in B6C3F1 mice (inhalation studies). Technical report series (Final). [Ethylene oxide]

Technical Report · Sun Nov 01 00:00:00 EST 1987

OSTI ID:5313818

Two-year toxicology and carcinogenesis studies of ethylene oxide were conducted by exposing groups of 50 B6C3F(1) mice of each sex to air containing 0, 50, or 100 ppm ethylene oxide 6 hours per day, 5 days per week for 102 weeks. Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity for B6C3F(1) mice as indicated by dose-related increased incidences of benign or malignant neoplasms of the lung and benign neoplasms of the harderian gland in both male and female B6C3F(1) mice following exposure to ethylene oxide vapors at 50 and 100 ppm. In female mice, ethylene oxide caused additional malignant neoplasms of the uterus, mammary gland, and hematopoietic system (lymphoma).

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 5313818
• Report Number(s): PB-88-169859/XAB; NTP-TR-326
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DISINFECTANTS
CARCINOGENESIS
BIOASSAY
INHALATION
LABORATORY ANIMALS
MICE
PROGRESS REPORT
TOXICITY
ANIMALS
DOCUMENT TYPES
GERMICIDES
INTAKE
MAMMALS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology