Mobilization of tissue cadmium in mice and calves and reversal of cadmium induced tissue damage in calves by zinc

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01689428· OSTI ID:5312850

Reddy, C S; Mohammad, F K; Ganjam, V K; Martino, M A; Brown, E M

Earlier studies demonstrated that simultaneous dietary Zn supplementation to calves fed Cd, significantly decreased the accumulation of Cd in liver, kidney and muscle. However, studies are lacking in evaluating the effectiveness of zinc in reducing Cd-burden in animals with pre-existing tissue Cd-load, a situation encountered in chronic Cd intoxication. This study examined the effects of oral Zn (AnO) on tissue Cd levels in mice. N-acetylcysteine (NAC) and sodium sulfate (SS) were also used to evaluate the effects of providing organic and inorganic sources of sulfur on tissue Cd levels. Following demonstration of reduced Cd levels in tissues of mice receiving antidotal Zn, subsequent investigation was aimed at studying the reversal of Cd-induced changes by Zn. The authors also examined whether Cd-induced reduction in epididymal 5 ..cap alpha..-reductase activity could explain previously reported low levels of circulating dihydrotestosterone (DHT) following Cd treatment. The ability of Zn to reverse the inhibition of 5 ..cap alpha..-reductase activity by Cd was also examined.

• Research Organization: Univ. of Missouri-Columbia (USA)
• OSTI ID: 5312850
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 39:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM COMPOUNDS
BIOLOGICAL EFFECTS
OXIDOREDUCTASES
INHIBITION
ZINC COMPOUNDS
CALVES
COPPER COMPOUNDS
ENZYME ACTIVITY
MICE
ANIMALS
CATTLE
DOMESTIC ANIMALS
ENZYMES
MAMMALS
RODENTS
RUMINANTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology