Residual, unresectable, or recurrent colorectal cancer: external beam irradiation and intraoperative electron beam boost +- resection

Journal Article · Tue Nov 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90411-X· OSTI ID:5300849

Gunderson, L L ^[1]; Cohen, A C; Dosoretz, D D; Shipley, W U; Hedberg, S E; Wood, W C; Rodkey, G V; Suit, H D

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1. Massachusetts General Hospital, Boston

While combinations of external beam radiation (XRT) and surgery decrease pelvic recurrence and improve survival in the subgroups with residual disease (postop XRT) or initially unresectable disease (preop XRT), local recurrence is still unacceptably high, and survival could be improved. In view of this, pilot studies were instituted at Massachusetts General Hospital in which 32 patients received the standard previous treatment of external beam irradiation and surgery but in addition had an intraoperative electron beam boost of 1000 to 1500 rad to the remaining tumor or tumor bed. For the 16 patients who presented with unresectable primary lesions, the addition of intraoperative radiotherapy has resulted in a total absence of local recurrence with a minimum 20 month follow-up, and survival rates are statistically better than for the previous group treated with only external beam irradiation and surgical resection. In the group with residual disease, again there have not been any local recurrences in the 7 patients who received all treatment modalities versus 54% and 26% for the group with gross and microscopic residual treated with only external beam techniques. The remaining 9 patients presented with recurrent unresectable lesions - 3 are alive (2 NED) at greater than or equal to 3 years.

• OSTI ID: 5300849
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:11
• Country of Publication: United States
• Language: English

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