The role of oxygen free radicals in the development of chronic renal failure

Journal Article · Wed Jan 01 00:00:00 EST 1992 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90548-4· OSTI ID:5299811

Trachtman, H; Wilson, D; Rao, P S ^[1]

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1. Albert Einstein College of Medicine, New Hyde Park, NY (United States)

This study examined whether there is increased production of oxygen free radicals during chronic renal failure. Rats subjected to 3/4 nephrectomy and sham operated controls were killed after 3 weeks. Lipid extracts of plasma and renal tissue were examined by HPLC and kidney specimens were also analyzed by EPR spectroscopy. The redox capacity of blood was assessed using nitroblue tetrazolium and plasma ascorbate levels were measured with HPLC. There was no detectable renal production of oxygen free radicals in rats with chronic renal failure. Kidney parenchymal content of other oxidants and the oxidant: reductant ratio were similar in control and uremic animals. The plasma redox capacity and ascorbate levels were elevated in uremic rats. The authors conclude that early in the course of chronic renal failure, there is not excessive production of oxygen free radicals. There is accumulation of reductants, primarily ascorbate, in the plasma of uremic animals.

• OSTI ID: 5299811
• Journal Information: Life Sciences; (United States), Vol. 50:24; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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