Functional asplenia in patients with chronic graft-versus-host disease: concise communication
Liver/spleen images were performed with technetium-99m sulfur colloid in 53 patients who had undergone bone-marrow transplantation. The spleen was not seen in the images in five out of the ten patients with chronic graft-versus-host disease (GVHD). None of the five had a history of splenectomy, In two of these patients, anatomical presence of the spleen had been documented earlier by scintigram. The spleen was visible in all seven patients with acute and in all 36 patients without GVHD. Neither the differences in methods of treating the patients before bone-marrow transplantation nor the time lapse between transplantation and the liver/spleen image correlated with the observed effect among these three groups of transplant patients. The authors conclude that there is a high association between chronic GVHD and functional asplenia.
- Research Organization:
- Johns Hopkins Medical Inst., Baltimore, MD
- OSTI ID:
- 5299217
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 24:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
GRAFT-HOST REACTION
PATHOLOGY
SPLEEN
BIOLOGICAL FUNCTIONS
SCINTISCANNING
TECHNETIUM 99
ANEMIAS
BONE MARROW
ISOMERIC NUCLEI
PATIENTS
RADIOCOLLOIDS
SULFUR COMPOUNDS
TRANSPLANTS
WHOLE-BODY IRRADIATION
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
EXTERNAL IRRADIATION
FUNCTIONS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques