Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma

Journal Article · Tue Dec 01 00:00:00 EST 1987 · Biochem. Med. Metab. Biol.; (United States)

DOI:https://doi.org/10.1016/0885-4505(87)90091-0· OSTI ID:5298604

Begum, V H; Sadique, J

The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of /sup 35/S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg/sup 2 +/ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.

• Research Organization: Tamil Univ. (India)
• OSTI ID: 5298604
• Journal Information: Biochem. Med. Metab. Biol.; (United States), Vol. 38:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ATP-ASE
ENZYME ACTIVITY
GLUCOPROTEINS
BIOSYNTHESIS
OXIDOREDUCTASES
SHRUBS
BIOLOGICAL EFFECTS
ADP
GRANULOMAS
HYDROCORTISONE
INHIBITION
MITOCHONDRIA
PHOSPHORYLATION
RATS
SULFATES
SULFUR 35
ACID ANHYDRASES
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOHYDRATES
CELL CONSTITUENTS
CHEMICAL REACTIONS
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ENZYMES
EVEN-ODD NUCLEI
GLUCOCORTICOIDS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
ISOTOPES
KETONES
LIGHT NUCLEI
MAMMALS
NEOPLASMS
NUCLEI
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANOIDS
OXYGEN COMPOUNDS
PHOSPHOHYDROLASES
PLANTS
PREGNANES
PROTEINS
RADIOISOTOPES
RODENTS
SACCHARIDES
STEROID HORMONES
STEROIDS
SULFUR COMPOUNDS
SULFUR ISOTOPES
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques