Neuropsychological sequelae of postradiation somnolence syndrome
Postirradiation somnolence syndrome in children with acute lymphocytic leukemia treated with cranial irradiation has been identified as a possible precursor of later cognitive dysfunction. To test this, the neuropsychological evaluation of 48 children who developed somnolence syndrome was compared with that of 31 children who did not have the syndrome at approximately 1 1/2 and 3 3/4 years after treatment. No differences in performance between the two groups were found on many measures of neuropsychological functioning with the exception of fine motor speed. Children without somnolence syndrome scored somewhat less than normal on measures of academic achievement. No other differences from normal performance were noted in either group. The results of the study indicated that if children with somnolence are at greater risk for the development of cognitive dysfunction than those not manifesting the syndrome, such risks occur at a time farther from treatment than 3 to 4 years.
- Research Organization:
- Division of Neurology, Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee
- OSTI ID:
- 5295750
- Journal Information:
- JDBP; (United States), Vol. 4:2
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
BIOLOGICAL RADIATION EFFECTS
LEUKEMIA
RADIOTHERAPY
SIDE EFFECTS
CHILDREN
NEUROLOGY
PATIENTS
SLEEP
AGE GROUPS
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
HEMIC DISEASES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
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560151* - Radiation Effects on Animals- Man
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