Comparative study of inactivation of herpes simplex virus types 1 and 2 by commonly used antiseptic agents

Journal Article · Mon Feb 01 00:00:00 EST 1988 · J. Clin. Microbiol.; (United States)

OSTI ID:5288460

Croughan, W S; Behbehani, A M

A comparative study of the different reactions of herpes simplex virus types 1 and 2 to Lysol, Listerine, bleach, rubbing alcohol, Alcide disinfectant (Alcide Corp., Westport, Conn.), and various pHs, temperatures, and UV light exposures was performed. Both types of stock virus (titers of approximately 10(6) and 10(5.5) for types 1 and 2, respectively) were inactivated by 0.5% Lysol in 5 min; by Listerine (1:1 mixtures) in 5 min; by 2000 ppm (2000 microliters/liter) of bleach in 10 min; by rubbing alcohol (1:1 mixtures) at zero time; by Alcide disinfectant (0.2 ml of virus plus 2.0 ml of Alcide) at zero time; by pHs 3, 5, and 11 in 10 min; and by a temperature of 56 degrees C in 30 min. A germicidal lamp at a distance of 48 cm failed to completely inactivate the two types in 15 min. Type 1 showed slightly more resistance to Listerine and bleach and significantly more resistance to heat; moreover, pH 9 did not affect the infectivity of either type after 10 min.

• Research Organization: Univ. of Kansas Medical Center, Kansas City (USA)
• OSTI ID: 5288460
• Journal Information: J. Clin. Microbiol.; (United States), Vol. 26:2
• Country of Publication: United States
• Language: English

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