Behavioral interactions between ethanol and imidazodiazepines with high affinities for benzodiazepine receptors

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90168-3· OSTI ID:5277343

Lister, R G

The intrinsic effect of two imidazodiazepines RO 15-3505 and RO 17-1812 on the behavior of mice in a holeboard test were investigated. The interactions of these two drugs with ethanol were also studied. RO 15-3505 failed to significantly alter either exploratory head-dipping or locomotor activity when administered alone but doses of 0.75 and 1.5 mg/kg reversed the reduction in the number of head-dips caused by ethanol and partially reversed ethanol's locomotor stimulant action. In contrast, RO 17-1812 increased locomotor activity when administered alone, and enhanced the reduction in exploration caused by ethanol. Neither RO 15-3505 nor RO 17-1812 altered blood alcohol concentrations suggesting a pharmacodynamic basis for these interactions. The results suggest that in the holeboard test the interactions of imidazodiazepines with ethanol are related to the nature of their interaction with benzodiazepine receptors, inverse agonists antagonising and agonists enhancing ethanol's effects on exploration.

• Research Organization: NIAAA, Bethesda, MD (USA)
• OSTI ID: 5277343
• Journal Information: Life Sci.; (United States), Vol. 42:14
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
TOXICITY
MICE
BEHAVIOR
TRANQUILIZERS
BIOLOGICAL EFFECTS
RECEPTORS
ALCOHOLS
ANIMALS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HYDROXY COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
PROTEINS
PSYCHOTROPIC DRUGS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology