Effect of oral administration of mutagens found in food on the frequency of sister chromatid exchanges in the colonic epithelium of mice

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2850100211· OSTI ID:5276942

Couch, D B; Stuart, E; Heddle, J A

Epidemiological studies indicate there is a link between dietary factors and the incidence of colon cancer, and it has been suggested mutagens in foods might be responsible for initiating the carcinogenic process. Some food mutagens are formed during the cooking process. For example, certain heterocyclic amines, including Trp-P-2 (3-amino-1-methyl-5H-pyrido(4,3-n) indole) and MeIQ (2-amino-3,4-dimethylimidazo(4,5-f)quinoline), which have been isolated from broiled meat and fish at low (ng/g) levels, are extremely potent mutagens in the Ames Salmonella/microsome test and can induce mutation in cultured mammalian cells as well. Other mutagens in foods are natural products; quercetin, a flavanoid widely distributed in plant products, is mutagenic to Salmonella and cultured mammalian cells. As most of the evidence implicating substance in food as mutagenic carcinogens comes from in vitro studies, it is of interest to determine whether these compounds can also exert genotoxic effects in vivo, particularly in colonic tissue. The ability to induce nuclear aberrations in vivo in murine colonic epithelial tissue has been suggested to be a property of colon carcinogens specifically, and several mutagens found in cooked food, including MeIQ and Trp-P-2, have been found to produce such nucleotoxicity. The authors report here tests of the ability of MeIQ, Trp-P-2, and quercetin to induce sister chromatid exchanges (SCEs) in the colonic epithelium of mice.

• Research Organization: Ludwig Institute for Cancer Research, Toronto, Ontario (Canada)
• OSTI ID: 5276942
• Journal Information: Environ. Mutagen.; (United States), Vol. 10:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
INDOLES
GENETIC EFFECTS
MUTAGENS
ORAL ADMINISTRATION
QUERCETIN
QUINOLINES
EPITHELIUM
FOOD
FOOD PROCESSING
IN VIVO
LARGE INTESTINE
MICE
SISTER CHROMATID EXCHANGES
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZINES
AZOLES
BIOLOGICAL EFFECTS
BODY
CHROMOSOMAL ABERRATIONS
DIGESTIVE SYSTEM
FLAVENOIDS
FLAVONES
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTESTINES
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROCESSING
PYRANS
PYRIDINES
PYRROLES
RODENTS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology