Vascular grafts in microvascular surgery. An experimental study

Journal Article · Mon Feb 01 00:00:00 EST 1988 · Am. J. Surg.; (United States)

DOI:https://doi.org/10.1016/S0002-9610(88)80709-8· OSTI ID:5271617

Marrangoni, A G; Marcelli, G; Culig, M; Simone, S T

The patency of microvascular grafts depends on the luminal diameter, which is determined by the amount of fibrin and platelets deposited on the intraluminal surface and the anastomotic site, and the extent of pseudointimal formation. An experimental microvascular model in rats has been developed in our laboratory using Indium-111-labeled platelets to measure the amount of deposition on grafts inserted into the infrarenal aorta. This study was designed to assess the patency rates in these grafts and the pathologic maturation as determined by light and electron microscopy. Our study suggests that substantial patency rates can be achieved in aspirin-treated rats, although there was little influence on the pathologic maturation. Indium-111 oxine-labeled platelets can be used to document platelet aggregation, and the technique can be a valuable adjunct in the study of microvascular grafts.

• Research Organization: Mercy Hospital, Pittsburgh, PA (USA)
• OSTI ID: 5271617
• Journal Information: Am. J. Surg.; (United States), Vol. 155:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BLOOD VESSELS
GRAFTS
SURGERY
AORTA
BIOLOGICAL MODELS
BLOOD PLATELETS
ELECTRON MICROSCOPY
INDIUM 111
ORGANOMETALLIC COMPOUNDS
OXINE
POLYTETRAFLUOROETHYLENE
RATS
TRACER TECHNIQUES
ANIMALS
AROMATICS
ARTERIES
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
FLUORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEDICINE
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYETHYLENES
POLYMERS
POLYOLEFINS
PYRIDINES
QUINOLINES
RADIOISOTOPES
RODENTS
TRANSPLANTS
VERTEBRATES
550600* - Medicine
550901 - Pathology- Tracer Techniques