Airway response to ultra short-term exposure to ozone
Abstract
To determine whether acute short-term exposure to oxidant pollutants can cause changes in respiratory mechanics, we gave 0.5 ppm ozone for 5 min to 7 baboons. We measured pulmonary resistance (RL) and obtained dose response curves to methacholine before and after the exposures. This brief insult increased resistance (control RL = 1.53 +/- 0.21 cm H/sub 2/O.L-1 s; post-ozone RL = 3.53 +/- 0.54 cm H/sub 2/O.L-1 s). On a second occasion, 6 of these animals were restudied before and after the administration of cromolyn sodium. Although this drug had no effect on the measurements of mechanics made in the control period, it significantly reduced the ozone-induced changes in mechanics. The increase in RL was 52% of that produced in the first study. The results demonstrated that the ozone injury with its acute and subacute airway sequelae occurs quite rapidly and after very brief exposure. The time course of the change in mechanics and the effects of cromolyn suggest the hypothesis that surface epithelial cells are disrupted, causing subsequent release of bronchoconstricting agents.
- Authors:
- Publication Date:
- Research Org.:
- Southwest Foundation for Biomedical Research, San Antonio, TX (USA)
- OSTI Identifier:
- 5270038
- Resource Type:
- Journal Article
- Journal Name:
- Am. Rev. Respir. Dis.; (United States)
- Additional Journal Information:
- Journal Volume: 137:2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OZONE; TOXICITY; RESPIRATORY SYSTEM; DYNAMIC FUNCTION STUDIES; ACUTE EXPOSURE; AIR POLLUTION; BABOONS; DOSE-RESPONSE RELATIONSHIPS; RESPONSE MODIFYING FACTORS; ANIMALS; MAMMALS; MONKEYS; POLLUTION; PRIMATES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology
Citation Formats
Fouke, J M, Delemos, R A, and McFadden, Jr, E R. Airway response to ultra short-term exposure to ozone. United States: N. p., 1988.
Web. doi:10.1164/ajrccm/137.2.326.
Fouke, J M, Delemos, R A, & McFadden, Jr, E R. Airway response to ultra short-term exposure to ozone. United States. https://doi.org/10.1164/ajrccm/137.2.326
Fouke, J M, Delemos, R A, and McFadden, Jr, E R. 1988.
"Airway response to ultra short-term exposure to ozone". United States. https://doi.org/10.1164/ajrccm/137.2.326.
@article{osti_5270038,
title = {Airway response to ultra short-term exposure to ozone},
author = {Fouke, J M and Delemos, R A and McFadden, Jr, E R},
abstractNote = {To determine whether acute short-term exposure to oxidant pollutants can cause changes in respiratory mechanics, we gave 0.5 ppm ozone for 5 min to 7 baboons. We measured pulmonary resistance (RL) and obtained dose response curves to methacholine before and after the exposures. This brief insult increased resistance (control RL = 1.53 +/- 0.21 cm H/sub 2/O.L-1 s; post-ozone RL = 3.53 +/- 0.54 cm H/sub 2/O.L-1 s). On a second occasion, 6 of these animals were restudied before and after the administration of cromolyn sodium. Although this drug had no effect on the measurements of mechanics made in the control period, it significantly reduced the ozone-induced changes in mechanics. The increase in RL was 52% of that produced in the first study. The results demonstrated that the ozone injury with its acute and subacute airway sequelae occurs quite rapidly and after very brief exposure. The time course of the change in mechanics and the effects of cromolyn suggest the hypothesis that surface epithelial cells are disrupted, causing subsequent release of bronchoconstricting agents.},
doi = {10.1164/ajrccm/137.2.326},
url = {https://www.osti.gov/biblio/5270038},
journal = {Am. Rev. Respir. Dis.; (United States)},
number = ,
volume = 137:2,
place = {United States},
year = {Mon Feb 01 00:00:00 EST 1988},
month = {Mon Feb 01 00:00:00 EST 1988}
}