Benefit, risk, and optimization by ROC analysis in cancer radiotherapy

Conference · Thu Aug 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5269310

Andrews, J R

The objective of definitive cancer radiation therapy is cure or control. The attainment of that objective is not without risk of treatment-induced radiation injury. The optimum treatment is, therefore, that level of radiotherapeutic effect with the maximum probability of benefit and the minimum associated probability of injury. An objective of radiotherapy research is the formulation of a model of optimization that is independent of a consensus of what constitutes optimization. Receiver operating characteristic (ROC) analysis is such a model, for it can relate probabilities of benefit and injury yielding a graphical determination of the optimum level of radiotherapeutic effect. ROC analysis is explained, an example taken from the contemporary radiotherapy literature is presented, and clinical research requirements for a general application of ROC analysis to the optimization of definitive cancer radiotherapy are developed.

• Research Organization: Georgetown Univ. Medical Center, Washington, DC
• OSTI ID: 5269310
• Report Number(s): CONF-8410325-
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:8; Conference: 26. annual meeting of the American Society of Therapeutic Radiology and Oncology, Washington, DC, USA, 8 Oct 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
RADIATION INJURIES
PROBABILITY
RADIOTHERAPY
RISK ASSESSMENT
MATHEMATICAL MODELS
NEOPLASMS
PATIENTS
RADIATION DOSES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOSES
INJURIES
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)