Demonstration of clonable alloreactive host T cells in a primate model for bone marrow transplantation
The phenomenon of marrow rejection following supralethal radiochemotherapy was explained in the past mainly by non-T-cell mechanisms known to be resistant to high-dose irradiation. In the present study a low but significant number of radiochemoresistant-clonable T cells was found in the peripheral blood and spleen of Rhesus monkeys following the cytoreductive protocol used for treatment of leukemia patients prior to bone marrow transplantation. More than 95% of the clonable cells are concentrated in the spleen 5 days after transplant. The cells possess immune memory as demonstrated by the generation of alloreactive-specific cytotoxicity. The present findings suggest that host-versus-graft activity may be mediated by alloreactive T cells. It is hoped that elimination of such cells prior to bone marrow transplantation will increase the engraftment rate of HLA-nonidentical marrow in leukemia patients.
- Research Organization:
- Weizmann Institute of Science, Rehovot (Israel)
- OSTI ID:
- 5268962
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 11
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW
TRANSPLANTS
SPLEEN CELLS
IMMUNOSUPPRESSION
CELL CYCLE
CLONE CELLS
GRAFT-HOST REACTION
LYMPH NODES
MACACUS
RADIOTHERAPY
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CELL CULTURES
HEMATOPOIETIC SYSTEM
LYMPHATIC SYSTEM
MAMMALS
MEDICINE
MONKEYS
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIOLOGY
SOMATIC CELLS
THERAPY
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals