Alternating radiotherapy and chemotherapy schedules in small cell lung cancer, limited disease
Sixty-three evaluable patients with limited small cell lung carcinoma were entered into two pilot studies alternating 6 cycles of combination chemotherapy with 3 courses of mediastinal radiotherapy as induction treatment. The first course of radiotherapy started 10 days after the second cycle of chemotherapy; there was a 7 day rest between chemotherapy and radiotherapy courses. This 6 month induction treatment was followed by a maintenance chemotherapy. The total mediastinal radiation dose was increased from 4500 rad in the first study to 5500 rad in the second. Both protocols obtained a complete response (CR) rate of greater than 85%. Local control at 2 years was 61% in the first study and 82% in the second. Acute and delayed toxicity effects are discussed.
- Research Organization:
- Institut Gustave-Roussy, Villejuif, France
- OSTI ID:
- 5266361
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:8
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
CHEMOTHERAPY
RADIOTHERAPY
SIDE EFFECTS
ESOPHAGUS
DELAYED RADIATION EFFECTS
MEDIASTINUM
RADIATION DOSES
PERICARDIUM
SKIN
DOXORUBICIN
ENDOXAN
FIBROSIS
INFLAMMATION
LUNGS
METHOTREXATE
NAUSEA
PATIENTS
PLATINUM COMPLEXES
VOMITING
ALKYLATING AGENTS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMETABOLITES
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CHEST
COMPLEXES
DIGESTIVE SYSTEM
DISEASES
DOSES
DRUGS
HEART
IMMUNOSUPPRESSIVE DRUGS
MEDICINE
MEMBRANES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
SEROUS MEMBRANES
SYMPTOMS
THERAPY
TRANSITION ELEMENT COMPLEXES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine
560151 - Radiation Effects on Animals- Man