Copper, iron and zinc absorption, retention and status of young women fed vitamin B-6 deficient diets

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5265355

Turnlund, J R; Keyes, W R; Hudson, C A; Betschart, A A; Kretsch, M J; Sauberlich, H E ^[1]

---

1. USDA/ARS, San Francisco, CA (United States) Western Regional Research Center, Albany, CA (United States)

A study was conducted in young women to determine the effect of vitamin B-6 deficient diets on copper, iron and zinc metabolism. Young women were confined to a metabolic research unit for 84 and 98 days. They were fed a vitamin B-6 deficient formula diet initially, followed by food diet containing four increasing levels of vitamin B-6. Copper, iron and zinc absorption, retention and status were determined at intervals throughout the study. Absorption was determined using the stable isotopes {sup 65}Cu, {sup 54}Fe, and {sup 67}Zn. Status was based on serum copper and zinc, hemoglobin, hematocrit and mean corpuscular volume. Copper absorption averaged 18 {plus minus} 1% during vitamin B-6 depletion, significantly lower than 24 {plus minus} 1% during repletion, but serum copper was not affected and balance was positive. Iron absorption was not impaired significantly by vitamin B-6 deficient diets, but status declined during the depletion period. Zinc absorption averaged 40 {plus minus} 2% during depletion and 27 {plus minus} 2% during repletion. Zinc absorption and retention were significantly greater during vitamin B-6 depletion, but serum zinc declined suggesting the absorbed zinc was not available for utilization. The results suggest that vitamin B-6 depletion of young women may inhibit copper absorption, affect iron status and alter zinc metabolism. The effects of vitamin B-6 depletion differ markedly among these elements.

• OSTI ID: 5265355
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
METABOLISM
IRON
VITAMIN B GROUP
BIOLOGICAL EFFECTS
ZINC
ABSORPTION
BLOOD COUNT
COPPER 65
DIET
HEMOGLOBIN
INHIBITION
IRON 54
RETENTION
TRACER TECHNIQUES
WOMEN
ZINC 67
ANIMALS
CARBOXYLIC ACIDS
COPPER ISOTOPES
ELEMENTS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FEMALES
GLOBINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
STABLE ISOTOPES
TRANSITION ELEMENTS
VERTEBRATES
VITAMINS
ZINC ISOTOPES
560300* - Chemicals Metabolism & Toxicology