Effects of macrocyclic trichothecene mycotoxins on the murine immune system
The macrocyclic trichothecenes are a unique group of toxins which have some antileukemic properties. In the first study, verrucarin A and roridin A were examined. Both mycotoxins were administered intraperitoneally at an equitoxic dose of 0.35 mg/kg to CD-1 mice. Lymphocyte proliferation was studied after animals were dosed with verrucarin A. After day 2, no differences in {sup 3}H-thymidine incorporation were observed using concanavalin A (Con A), phytohemagglutinin (PHA), pokeweed mitogen (PWM), or lipopolysaccharide (LPS). On day 4, DNA synthesis induced by Con A, PHA, and PWM increased significantly. On day 7, PHA stimulation increased above controls while Con A, PWM, and LPS responses were not significantly different. In contrast, roridin A decreased PHA stimulation only on day 7. In the second study the mycotoxins roritoxin B, myrotoxin B, roridin A, verrucarin A, 16-hydroxyverrucarin A, verrucarin J, baccharinoid B12, roridin D, roridin E, baccharinoid B4, and baccharinoid B5 were investigated. In the third study lymphocytes were cultured with each of the mycotoxins for 48 hr to assess their lethality.
- Research Organization:
- Utah State Univ., Logan, UT (USA)
- OSTI ID:
- 5265281
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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CELL PROLIFERATION
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
TOXINS
BIOLOGICAL EFFECTS
CONCANAVALIN
INTRAPERITONEAL INJECTION
LIPOPOLYSACCHARIDES
MICE
MITOGENS
PHYTOHEMAGGLUTININ
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AGGLUTININS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIBODIES
ANTIGENS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
HEMAGGLUTININS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LEUKOCYTES
LIPIDS
MAMMALS
MATERIALS
MUCOPROTEINS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLYSACCHARIDES
PROTEINS
PYRIMIDINES
RIBOSIDES
RODENTS
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SOMATIC CELLS
TISSUES
TOXIC MATERIALS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques