Malignant melanoma of the eye: treatment of posterior uveal lesions by Co-60 plaque radiotherapy versus enucleation
Survival rates and visual acuity of 100 patients treated for posterior uveal malignant melanoma by cobalt-60 plaque radiotherapy were compared with 150 patients treated by enucleation for the same disease. Life-table comparisons of the entire group showed significant differences in survival rates, with plaque radiotherapy patients appearing to fare better. However, when patients with small or medium tumors were compared, only slight differences were seen, implying that criteria used to select patients for treatment may affect interpretation. The two groups were also compared using the Cox proportional hazards model, which predicts survival based on the impact of clinical variables. In this analysis, the survival rates of the plaque radiotherapy group were no worse than those of the enucleation group. The advantage of conservative therapy lies in the potential to preserve useful vision over a considerable time.
- Research Organization:
- Hahnemann Univ. College of Medicine, Philadelphia, PA
- OSTI ID:
- 5265196
- Report Number(s):
- CONF-851152-; TRN: 85-022521
- Journal Information:
- Radiology; (United States), Vol. 156:3; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
- Country of Publication:
- United States
- Language:
- English
Similar Records
Enucleation vs cobalt plaque radiotherapy for malignant melanomas of the choroid and ciliary body
Uveal Melanoma Treated With Iodine-125 Episcleral Plaque: An Analysis of Dose on Disease Control and Visual Outcomes
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
BIOLOGICAL RADIATION EFFECTS
MELANOMAS
RADIOTHERAPY
COBALT 60
COMPARATIVE EVALUATIONS
GAMMA RADIATION
PATIENTS
SURGERY
SURVIVAL TIME
UVEA
VISION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
COBALT ISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
FACE
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
SENSE ORGANS
THERAPY
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)