Measurement of human cerebral blood flow with (15O)butanol and positron emission tomography

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Journal of Cerebral Blood Flow and Metabolism; (United States)

DOI:https://doi.org/10.1038/jcbfm.1991.127· OSTI ID:5265034

Berridge, M S; Adler, L P; Nelson, A D; Cassidy, E H; Muzic, R F; Bednarczyk, E M; Miraldi, F ^[1]

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1. Case Western Reserve University, School of Medicine, Cleveland, OH (USA)

Although H2(15)O is widely used for CBF measurement by positron tomography, it underestimates CBF, especially at elevated flow rates. Several tracers, including butanol, overcome this problem, but the short half-life of 15O provides advantages that cause water to remain the tracer of choice. The authors report the first use and evaluation of 15O-labeled butanol for CBF measurement. Flow measurements made in a similar fashion with water and butanol at 10-min intervals were compared in normal volunteers under resting and hypercapnic conditions. Regional analysis showed good agreement between the tracers at low flows, and significant underestimation of flow by water relative to butanol in regions of elevated flow. The observed relationship between the tracers and the curve-fitted permeability-surface area product for water (133 ml.100 g-1.min-1) follow the known relationship between water and true flow. These observations indicate that (15O)-butanol provided accurate measurements of human regional CBF under conditions of elevated perfusion. They conclude that butanol is a convenient and accurate method for routine CBF determination by positron emission tomography.

• OSTI ID: 5265034
• Journal Information: Journal of Cerebral Blood Flow and Metabolism; (United States), Vol. 11:5; ISSN 0271-678X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
POSITRON COMPUTED TOMOGRAPHY
CEREBRAL CORTEX
BLOOD FLOW
VASCULAR DISEASES
DIAGNOSIS
BUTANOLS
MAN
OXYGEN 15
WATER
ALCOHOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics