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Title: Synthesis of carbon-11, fluorine-18, and nitrogen-13 labeled radiotracers for biomedical applications

Synthesis of carbon-11, fluorine-18, and nitrogen-13 labeled radiotracers for biomedical applications A number of reviews, many of them recent, have appeared on various aspects of /sup 11/C, /sup 18/F and /sup 13/N-labeled radiotracers. This monograph treats the topic principally from the standpoint of synthetic organic chemistry while keeping in perspective the necessity of integrating the organic chemistry with the design and ultimate application of the radiotracer. Where possible, recent examples from the literature of organic synthesis are introduced to suggest potentially new routes which may be applied to problems in labeling organic molecules with the short-lived positron emitters, carbon-11, fluorine-18, and nitrogen-13. The literature survey of carbon-11, fluorine-18 and nitrogen-13 labeled compounds presented are of particular value to scientists working in this field. Two appendices are also included to provide supplementary general references. A subject index concludes this volume.
Authors: ;
Publication Date:
OSTI Identifier:OSTI ID: 5260761
Report Number(s):BNL-31222
ON: DE82013799; TRN: 82-013604
DOE Contract Number:AC02-76CH00016
Resource Type:Technical Report
Resource Relation:Other Information: Portions of document are illegible
Research Org:Brookhaven National Lab., Upton, NY (USA)
Country of Publication:United States
Language:English
Subject: 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; CARBON 11; RADIOCHEMISTRY; FLUORINE 18; LABELLED COMPOUNDS; SYNTHESIS; USES; NITROGEN 13; ORGANIC COMPOUNDS; LABELLING; RADIOPHARMACEUTICALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMISTRY; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES 400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials