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Title: A broader perspective of sexual differentiation

Abstract

Human sexual differentiation is customarily depicted as a series of embryonic events that lead to male and female gonadal development and differential hormone expression that have behavioral as well as biological outcomes. The salient components of these events are the differential expression of two hormones - testosterone and Muellerian inhibiting substance - and the SRY gene, regulating, in turn, the transcription of other genes and culminating in male differentiation. Sex determination, then, is generally described as initially proceeding down a path toward female development unless the bipotential, indifferent gonad is modified toward male development by genes on the Y chromosome. 28 refs.

Authors:
 [1];  [2]
  1. DePaul Univ., Chicago, IL (United States)
  2. Northwestern Univ. Medical School, Chicago, IL (United States)
Publication Date:
OSTI Identifier:
525997
Resource Type:
Journal Article
Journal Name:
American Journal of Medical Genetics
Additional Journal Information:
Journal Volume: 69; Journal Issue: 3; Other Information: PBD: 31 Mar 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN Y CHROMOSOME; GENETIC MAPPING; GENES; TRANSCRIPTION; GENE REGULATION; EMBRYOS; ONTOGENESIS; SEX; HUMAN CHROMOSOMES; CHROMOSOMAL ABERRATIONS; GONADS; GENETICS; PHENOTYPE; HORMONES; TESTOSTERONE

Citation Formats

Fiddler, M, and Pergament, E. A broader perspective of sexual differentiation. United States: N. p., 1997. Web. doi:10.1002/(SICI)1096-8628(19970331)69:3<229::AID-AJMG2>3.0.CO;2-G.
Fiddler, M, & Pergament, E. A broader perspective of sexual differentiation. United States. https://doi.org/10.1002/(SICI)1096-8628(19970331)69:3<229::AID-AJMG2>3.0.CO;2-G
Fiddler, M, and Pergament, E. 1997. "A broader perspective of sexual differentiation". United States. https://doi.org/10.1002/(SICI)1096-8628(19970331)69:3<229::AID-AJMG2>3.0.CO;2-G.
@article{osti_525997,
title = {A broader perspective of sexual differentiation},
author = {Fiddler, M and Pergament, E},
abstractNote = {Human sexual differentiation is customarily depicted as a series of embryonic events that lead to male and female gonadal development and differential hormone expression that have behavioral as well as biological outcomes. The salient components of these events are the differential expression of two hormones - testosterone and Muellerian inhibiting substance - and the SRY gene, regulating, in turn, the transcription of other genes and culminating in male differentiation. Sex determination, then, is generally described as initially proceeding down a path toward female development unless the bipotential, indifferent gonad is modified toward male development by genes on the Y chromosome. 28 refs.},
doi = {10.1002/(SICI)1096-8628(19970331)69:3<229::AID-AJMG2>3.0.CO;2-G},
url = {https://www.osti.gov/biblio/525997}, journal = {American Journal of Medical Genetics},
number = 3,
volume = 69,
place = {United States},
year = {Mon Mar 31 00:00:00 EST 1997},
month = {Mon Mar 31 00:00:00 EST 1997}
}