Determination of single and repeated red cell volumes by the indicator dilution method using carbon monoxide as the indicator

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Critical Care Medicine; (USA)

DOI:https://doi.org/10.1097/00003246-198911000-00020· OSTI ID:5259780

Fukui, M; Shigemi, K ^[1]

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1. Kyoto Prefectural Univ. of Medicine (Japan)

The use of radioactive isotopes limits clinical applications of blood volume measurement in the ICU. We measured red cell volumes with carbon monoxide-labeled RBC in six dogs and five human volunteers. The measured values obtained on the dogs were compared with the simultaneous measurements with the {sup 51}Cr method; the ratio of the carbon monoxide to {sup 51}Cr values ranged from 0.86 to 1.17, and the mean ratio was 1.0 +/- 0.1 (SD), r = .93. We infer from these results that the carbon monoxide method has several advantages over the {sup 51}Cr method: (a) the short labeling time (about 1 min), (b) rapidly decreasing background levels of carbon monoxide with FIO2 1.0, and (c) repeatability at intervals of several hours.

• OSTI ID: 5259780
• Journal Information: Critical Care Medicine; (USA), Vol. 17:11; ISSN 0090-3493
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ERYTHROCYTES
MEASURING METHODS
CARBON MONOXIDE
CHROMIUM 51
COMPARATIVE EVALUATIONS
DOGS
MAN
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
CHROMIUM ISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RADIOISOTOPES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques