Effect of thyroxine supplementation on the response to perfluoro-n-decanoic acid (PFDA) in rats

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Journal of Toxicology and Environmental Health; (USA)

DOI:https://doi.org/10.1080/15287398809531179· OSTI ID:5257358

Gutshall, D M; Pilcher, G D; Langley, A E

Perfluoro-n-decanoic acid (PFDA) is a member of a family of perfluorinated carboxylic acids that have found widespread commercial applications as lubricants, surfactants, wetting agents and corrosion inhibitors. The effects of thyroxine (T{sub 4}) supplementation on perfluoro-n-decanoic acid- (PFDA) induced decreases in food consumption, body weight, and body temperature were examined. A dose-response study was carried out with 50-, 100-, 200-, or 250-{mu}g/kg ip doses of T{sub 4} for 7 d prior to PFDA administration, and daily dosing with T{sub 4} was continued for an additional 30 d. From this study a T{sub 4} dose of 200 {mu}g/kg was chosen, and subsequent experiments were conducted with this dose. Supplementation with T{sub 4} at 200 {mu}g/kg daily alleviated the hypophagia but not the severe weight loss and hypothermia produced by PFDA treatment. Their results suggest that some component of the thyroid axis plays a role in feeding behavior. In addition, the PFDA-induced wasting syndrome and hypothermia appear to be unrelated to changes in serum thyroid hormones. The unexpected observation that severe weight loss occurred in the presence of essentially normal food intake suggests that PFDA alters basic cellular metabolic processes.

• OSTI ID: 5257358
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Vol. 24:4; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DECANOIC ACID
TOXICITY
FLUORINE COMPOUNDS
THYROXINE
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
HYPOTHERMIA
METABOLISM
RATS
WEIGHT
AMINO ACIDS
ANIMALS
BODY TEMPERATURE
CARBOXYLIC ACIDS
HALOGEN COMPOUNDS
HORMONES
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
PEPTIDE HORMONES
RODENTS
THYROID HORMONES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology