Bone kinetics of calcium-45 and pyrophosphate labeled with technetium-96: an autoradiographic evaluation. [Rabbits]
The uptake of calcium-45 and of pyrophosphate labeled with the long-lived technetium-96 isotope was compared by means of liquid-emulsion microautoradiograms of the epiphyseal plates of 10-week-old rabbits, at 30 min, and 3 and 48 hr after i.v administration. For both tracers, thin sections confirm the significant role of the blood supply, especially shortly after injection. However, other more specific mechanisms lead to a mixing of the calcium in the mineral mass and to a linear deposition of technetium facing the osteoid surfaces. These findings suggest that the tropism of tin-reduced technetium pyrophosphate is not governed by the mineral pool but rather by exchanges inside a still poorly calcified organic matrix.
- Research Organization:
- Hopital Neuro-Cardiologique, Lyon, France
- OSTI ID:
- 5243545
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BONE TISSUES
RADIONUCLIDE KINETICS
CALCIUM 45
BIOLOGICAL LOCALIZATION
TECHNETIUM 96
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
COMPARATIVE EVALUATIONS
INTRAVENOUS INJECTION
PYROPHOSPHATES
RABBITS
RADIOPHARMACEUTICALS
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RADIOACTIVE MATERIALS
RADIOISOTOPES
REACTION KINETICS
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics