Dose-response model for teratological experiments involving quantal responses

Journal Article · Fri Mar 01 00:00:00 EST 1985 · Biometrics; (United States)

DOI:https://doi.org/10.2307/2530637· OSTI ID:5241605

Rai, K; Van Ryzin, J

This paper introduces a dose-response model for teratological quantal response data where the probability of response for an offspring from a female at a given dose varies with the litter size. The maximum likelihood estimators for the parameters of the model are given as the solution of a nonlinear iterative algorithm. Two methods of low-dose extrapolation are presented, one based on the litter size distribution and the other a conservative method. The resulting procedures are then applied to a teratological data set from the literature.

• Research Organization: California State Polytechnic Univ., Pomona
• OSTI ID: 5241605
• Journal Information: Biometrics; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
TERATOGENS
BIOLOGICAL EFFECTS
ALGORITHMS
BIOLOGICAL MODELS
EXTRAPOLATION
LITTER SIZE
MATHEMATICS
PREGNANCY
PROBABILITY
PROGENY
MATHEMATICAL LOGIC
NUMERICAL SOLUTION
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)