Simulation of restricted neural networks with reprogrammable neurons
- Bekesey Lab. of Neurobiology, 1993 East-West Road, Honolulu, HI (US)
This paper describes a network model composed of reprogrammable neurons. It incorporates the following design features: spikes can be generated by a model representing repetitive firing at axon (and dendritic) trigger zones; active responses (plateau potentials; delaying mechanisms) are simulated with Hodgkin-huxley type kinetics; synaptic interactions both spike-mediated and non-spiking chemical ('chemotonic'), simulate transmitter release and binding to postsynaptic receptors. Facilitation and antifacilitation of spike-mediated postsynaptic potentials (PSP's) are included. Chemical pools are used to simulate second messenger systems, trapping of ions in extracellular spaces, and electrogenic pumps, as well as biochemical reaction chains of quite general character. Modulation of any of the parameters of any compartment can be effected through the pools. Intracellular messengers of three kinds are simulated explicitly: those produced by voltage-gated processes (e.g. Ca); those dependent on transmitter (or hormone) binding; and those dependent on other internal messengers (e.g., internally released Ca; enzymatically activated pathways).
- OSTI ID:
- 5238660
- Journal Information:
- IEEE (Institute of Electrical and Electronics Engineers) Transactions on Circuits and Systems; (USA), Vol. 36:5; ISSN 0098-4094
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NERVE CELLS
COMPUTERIZED SIMULATION
PARALLEL PROCESSING
DESIGN
ARRAY PROCESSORS
COMPUTER NETWORKS
IONS
LEARNING
PARAMETRIC ANALYSIS
PHYSIOLOGY
TRAPPING
ANIMAL CELLS
CHARGED PARTICLES
PROGRAMMING
SIMULATION
SOMATIC CELLS
990200* - Mathematics & Computers