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Title: Enhanced T-lymphocyte blastogenic response to tuberculin (PPD) in children of northeast (NE) Thailand supplemented with vitamin A (VA) and zinc (Zn)

Enhanced T-lymphocyte blastogenic response to tuberculin (PPD) in children of northeast (NE) Thailand supplemented with vitamin A (VA) and zinc (Zn) Beneficial effects of Va and/or Zn supplementation of children in NE Thailand are described in a companion abstract. In the same study, blastogenic response (BR) of T-lymphocytes to concanavalin-A (ConA) and PPD were assayed in cultures containing mononuclear cells (MNC) or whole blood (WB). Methods were previously described. Children were previously vaccinated with BCG. BR to ConA of MNC or WB from children supplemented with VA, Zn, VA + Zn or placebo were similar. BR to PPD of MNC was higher in children receiving VA + Zn than placebo, but not in children supplemented with VA or Zn alone. Data indicate that children with suboptimal VA and Zn nutriture supplemented with < 2 times RDA of these nutrients showed enhanced cellular immunity to PPD. This observation is relevant to BCG immunization program and thus may benefit public health.
Authors: ; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:OSTI ID: 5238319
Report Number(s):CONF-9104107--
Journal ID: ISSN 0892-6638; CODEN: FAJOE
Resource Type:Conference
Resource Relation:Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States); Journal Volume: 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991
Country of Publication:United States
Language:English
Subject: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TUBERCULIN; IMMUNITY; VITAMIN A; METABOLISM; ZINC; CHILDREN; CONCANAVALIN A; LYMPHOCYTES; NUTRITIONAL DEFICIENCY; THAILAND; AGE GROUPS; AGGLUTININS; ANIMAL CELLS; ANTIBODIES; ANTIGENS; ASIA; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DEVELOPING COUNTRIES; ELEMENTS; HEMAGGLUTININS; LECTINS; LEUKOCYTES; MATERIALS; METALS; SOMATIC CELLS; VITAMINS 560300* -- Chemicals Metabolism & Toxicology