Comparative metabolism of haloethers. [Bis(2-chloroisopropyl) ether, /sup 14/C, rats, monkeys]

Conference · Sat Jan 01 00:00:00 EST 1977 · Ann. N.Y. Acad. Sci.; (United States)

OSTI ID:5237835

Smith, C C ^[1]; Lingg, R D; Tardiff, R G

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1. Univ. of Cincinnati

Bis(2-chloroisopropyl) ether (BCIE) was labeled with /sup 14/C and administered to rats and monkeys and experiments were carried out in metabolic chambers. Urine, blood, and fecal samples were analyzed for BCIE by extraction with trimethylpentane (TMP). Seven days after administration, animals were killed and all organs were excised for analysis of radioactivity. Graphs are presented to show time course of BCIE and its metabolites in blood and cumulative urinary and fecal excretion of BCIE and its metabolites. Tables are presented to show tissue distributions in various organs of rats and monkeys. (HLW)

• OSTI ID: 5237835
• Journal Information: Ann. N.Y. Acad. Sci.; (United States), Vol. 298; Conference: Conference on aquatic pollutants and biologic effects with emphasis on neoplasia, New York, NY, USA, 27 Sep 1976; Other Information: See CONF-7609167--
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ETHERS
METABOLISM
TISSUE DISTRIBUTION
BLOOD
CARBON 14
EXCRETION
FECES
MONKEYS
RATS
URINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON ISOTOPES
CLEARANCE
DISTRIBUTION
EVEN-EVEN NUCLEI
ISOTOPES
LIGHT NUCLEI
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PRIMATES
RADIOISOTOPES
RODENTS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
550500* - Metabolism