Effects of single and repeated inhalation exposure of Syrian hamsters to aerosols of /sup 144/CeO/sub 2/

Journal Article · Sat May 01 00:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575715· OSTI ID:5237697

Lundgren, D L; Hahn, F F; McClellan, R O

Male Syrian hamsters (84 days old at the time of the initial exposure) were repeatedly exposed by inhalation at approximately 60-day intervals for 1 year (seven exposures) to aerosols of /sup 144/CeO/sub 2/ to reestablish lung burdens of 0.4, 2.0, or 10 ..mu..Ci of /sup 144/Ce. Other hamsters were exposed once when either 84, 220, or 360 days old to achieve similar initial lung burdens. Primary lung tumors were observed in 7 of 197 hamsters repeatedly exposed to /sup 144/CeO/sub 2/ that died between 177 and 685 days after the initial inhalation exposure. The cumulative adsorbed ..beta..-radiation doses to the lungs of these hamsters were 14,000 to 50,000 rad. Primary lung tumors also were observed in 6 of 153 hamsters exposed once to /sup 144/CeO/sub 2/ when 84 or 220 days old that died between 270 and 695 days after exposure. The cumulative ..beta..-radiation doses to the lungs of these hamsters were 6000 to 21,000 rad. Lung tumors were not observed in hamsters exposed when 360 days old or in control hamsters. The incidences of primary lung tumors were more dependent on the cumulative dose to the lung than the radiation dose pattern that resulted in the cumulative dose.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5237697
• Journal Information: Radiat. Res.; (United States), Vol. 90:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
61 RADIATION PROTECTION AND DOSIMETRY
CERIUM 144
INHALATION
CERIUM OXIDES
LINERS
DELAYED RADIATION EFFECTS
LUNGS
NEOPLASMS
RADIOINDUCTION
SKELETON
AEROSOLS
BODY BURDEN
CHRONIC EXPOSURE
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RADIATION DOSES
RETENTION
SURVIVAL TIME
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BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CERIUM COMPOUNDS
CERIUM ISOTOPES
CHALCOGENIDES
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DOSES
EVEN-EVEN NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
RARE EARTH COMPOUNDS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
RODENTS
SOLS
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655003 - Medical Physics- Dosimetry