Growth factors
Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of growth hormone. Epithelial growth factor and nerve growth factor are well-characterized polypeptides that influence the growth and differentiation of epithelial and neural tissues and interact with specific cell surface receptors. The hematopoietins are a family of polypeptide hormones that specifically regulate the proliferation and differentiation of stem cells giving rise to erythrocytes, granulocytes, monocytes, megakaryocytes, and B and T lymphocytes. Platelet-derived growth factor modulates the proliferation of fibroblasts in vitro and may have a role in the development of atherosclerosis and myelofibrosis. New knowledge on the biochemistry and physiology of growth factors will probably have a substantial impact on our understanding of human diseases involving abnormal cell growth.
- OSTI ID:
- 5237455
- Journal Information:
- Ann. Intern. Med.; (United States), Vol. 92:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Increased granulocytic, erythrocytic, and megakaryocytic progenitors in myelofibrosis with myeloid metaplasia
The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo
Related Subjects
SOMATIC CELLS
CELL PROLIFERATION
GROWTH
STEM CELLS
STH
BIOLOGICAL EFFECTS
BIOCHEMISTRY
HEMATOPOIETIC SYSTEM
PHYSIOLOGY
STIMULATION
ANIMAL CELLS
BODY
CHEMISTRY
HORMONES
PEPTIDE HORMONES
PITUITARY HORMONES
551000* - Physiological Systems
550200 - Biochemistry
550300 - Cytology